Journal of Movement Disorders

Original Article

Correlation of Sleep Disturbance and Cognitive Impairment in Patients with Parkinson’s Disease: Eun Ja Kim, Joon Hyun Baek, Dong Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Dong Hoon Shin, Young Noh, Young Hee Sung; J Mov Disord. 2014;7(1):13-18. Published online April 30, 2014; DOI: https://doi.org/10.14802/jmd.14003

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Objective: Cognitive impairment is a common nonmotor symptom of Parkinson’s disease (PD) and is associated with high mortality, caregiver distress, and nursing home placement. The risk factors for cognitive decline in PD patients include advanced age, longer disease duration, rapid eye movement sleep behavior disorder, hallucinations, excessive daytime sleepiness, and nontremor symptoms including bradykinesia, rigidity, postural instability, and gait disturbance. We conducted a cross-sectional study to determine which types of sleep disturbances are related to cognitive function in PD patients.
Methods: A total of 71 PD patients (29 males, mean age 66.46 ± 8.87 years) were recruited. All patients underwent the Mini- Mental State Examination (MMSE) and the Korean Version of the Montreal Cognitive Assessments (MoCA-K) to assess global cognitive function. Sleep disorders were evaluated with the Stanford Sleepiness Scale, Epworth Sleepiness Scale, Insomnia Severity Index (ISI), Pittsburg Sleep Quality Index, and Parkinson’s Disease Sleep Scale in Korea (PDSS).
Results: The ISI was correlated with the MMSE, and total PDSS scores were correlated with the MMSE and the MoCA-K. In each item of the PDSS, nocturnal restlessness, vivid dreams, hallucinations, and nocturnal motor symptoms were positively correlated with the MMSE, and nocturnal restlessness and vivid dreams were significantly related to the MoCA-K. Vivid dreams and nocturnal restlessness are considered the most powerful correlation factors with global cognitive function, because they commonly had significant correlation to cognition assessed with both the MMSE and the MoCA-K.

Conclusions: We found a correlation between global cognitive function and sleep disturbances, including vivid dreams and nocturnal restlessness, in PD patients.

Citations

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Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats
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Evaluation and validation of a patient-reported quality-of-life questionnaire for Parkinson’s disease
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Journal of Patient-Reported Outcomes.2022;[Epub] CrossRef
Poor sleep quality is associated with fatigue and depression in early Parkinson's disease: A longitudinal study in the PALS cohort
Matthew Rui En Koh, Cong Yang Chua, Samuel Yong-Ern Ng, Nicole Shuang-Yu Chia, Seyed Ehsan Saffari, Regina Yu-Ying Chen, Xinyi Choi, Dede Liana Heng, Shermyn Xiumin Neo, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Louis Chew-Seng Tan, Zheyu Xu
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Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease
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The impact of clinical scales in Parkinson’s disease: a systematic review
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Neuroscience Letters.2019; 699: 71. CrossRef
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Acta Neurologica Belgica.2018; 118(1): 85. CrossRef
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Case Reports

A Case of Action-Induced Clonus that Mimicked Action Tremors and was Associated with Cervical Schwannoma: Young-Hee Sung, Ki-Hyung Park, Yeung-Bae Lee, Hyeon-Mi Park, Dong-Jin Shin; J Mov Disord. 2010;3(2):48-50.; DOI: https://doi.org/10.14802/jmd.10013

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Abstract PDF: Clonus is the rhythmic muscle contraction which usually occurs in patients with lesions involving descending motor pathways. Sometimes, rhythmic oscillation of action induced clonus could be confused to action tremor. We report a case of action induced clonus associated with cervical schwannoma which was misdiagnosed as essential tremor. The patient had spasticity in all limbs with exaggerated tendon reflexes, and passive stretch-induced clonus. Imaging and histological examinations revealed a schwannoma extending from C2 to C7. The lesion was partially removed by surgery. Even though essential tremor is a common disease, clinician have to do sufficient neurologic examination considering differential diagnosis.

Chorea in the Both Lower Limbs Associated with Nonketotic Hyperglycemia: Young-Hee Sung, Ki-Hyung Park, Yeung-Bae Lee, Hyeon-Mi Park, Dong-Jin Shin; J Mov Disord. 2009;2(2):98-100.; DOI: https://doi.org/10.14802/jmd.09027

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4 Crossref

Abstract PDF

Hemichorea-hemiballism (HC-HB) is a complication of non-ketotic hyperglycemia (NKH); in NKH patients, the frequency of occurrence of HC-HB is greater than that of bilateral chorea. We report the case of a hyperglycemic patient who showed chorea in both the lower limbs. Magnetic resonance imaging (MRI) of the brain revealed high signal intensity on T1-weighted images of the bilateral dorsolateral putamen. The abnormal involuntary movements disappeared after oral administration of haloperidol. Our case report that chorea associated with NKH is correlated with the topography of the basal ganglia.

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Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review
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International Journal of Biological Macromolecules.2021; 193: 562. CrossRef
“Diabetic striatopathy”: clinical presentations, controversy, pathogenesis, treatments, and outcomes
Choon-Bing Chua, Cheuk-Kwan Sun, Chih-Wei Hsu, Yi-Cheng Tai, Chih-Yu Liang, I-Ting Tsai
Scientific Reports.2020;[Epub] CrossRef
T2*-based MR imaging of hyperglycemia-induced hemichorea-hemiballism
Fang Yu, Andrew Steven, Lee Birnbaum, Wilson Altmeyer
Journal of Neuroradiology.2017; 44(1): 24. CrossRef
Acute chorea in the diabetic nonketotic hyperosmolar state
Aaron de Souza, C. Shyam Babu, Paresh K. Desai
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Novel Compound Heterozygous Mutations in the Pantothenate Kinase 2 Gene in a Korean Patient with Atypical Pantothenate Kinase Associated Neurodegeneration: Sung-Hyouk Kim, Young-Hee Sung, Kee-Hyung Park, Yeung-Bae Lee, Hyeon-Mi Park, Dong Jin Shin, Gu-Hwan Kim; J Mov Disord. 2009;2(1):45-47.; DOI: https://doi.org/10.14802/jmd.09012

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80 Download
2 Crossref

Abstract PDF

Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal recessive disorder that is characterized by mutations in the pantothenate kinase 2 gene (PANK2) and typical magnetic resonance imaging findings. We report a case of atypical PKAN presenting with generalized dystonia. Our patient had compound heterozygous mutations in the PANK2 gene, including mutation in exon 3 (p.D268G) and exon 4 (p.R330P). To our knowledge, this patient is the first to have the p.R330P mutation and the second to have the p.D268G mutation.

Citations

Citations to this article as recorded by

Atypical pantothenate kinase-associated neurodegeneration: Clinical description of two brothers and a review of the literature
S. Mahoui, A. Benhaddadi, W. Ameur El Khedoud, M. Abada Bendib, M. Chaouch
Revue Neurologique.2017; 173(10): 658. CrossRef
Clinical Heterogeneity of Atypical Pantothenate Kinase-Associated Neurodegeneration in Koreans
Jae-Hyeok Lee, Jongkyu Park, Ho-Sung Ryu, Hyeyoung Park, Young Eun Kim, Jin Yong Hong, Sang Ook Nam, Young-Hee Sung, Seung-Hwan Lee, Jee-Young Lee, Myung Jun Lee, Tae-Hyoung Kim, Chul Hyoung Lyoo, Sun Ju Chung, Seong Beom Koh, Phil Hyu Lee, Jin Whan Cho,
Journal of Movement Disorders.2016; 9(1): 20. CrossRef

A Case of Chorea as the Initial Manifestation of SLE Triggered by Estrogen: Su-Hyun Kim, Dong-Jin Shin, Hyeon-Mi Park, Yeong-Bae Lee, Kee-Hyung Park, Young-Hee Sung; J Mov Disord. 2008;1(2):86-89.; DOI: https://doi.org/10.14802/jmd.08016

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Abstract PDF: Neurological complications of systemic lupus erythematosus (SLE) are relatively common, but chorea as the initial manifestation of SLE unmasked by exogenous estrogen is very rare. A-46-year old right handed woman presented with generalized chorea since 2 weeks ago. Her medical records revealed that the chorea had appeared within one month after estrogen medication. The laboratory test revealed positive antinuclear antibody (ANA), positive anti-dsDNA and positive anti-histone antibody. After discontinuation of estrogen, her choreic movement was not diminished. We report a case of newly diagnosed SLE attribute to chorea which triggered by estrogen.

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